postdoctoral scientist in immunology / rna biology

DETALLES DE LA OPORTUNIDAD

Recompensa total

0 $

Universidad Estatal

INSERM

Área

Europa Oriental

País anfitrión

Francia

Fecha límite

31 dic. 2020

Nivel de estudio

Doctorado

Tipo de oportunidad

Postdoctorado

Especialidades

Biología

Oportunidad de financiación

Financiación completa

Países elegibles

Esta oportunidad está destinada a todos los países

Región elegible

Todas las regiones

Post-transcriptional regulation by RNA-binding proteins (RBPs) controls all aspects of RNA life, from synthesis, editing, location and translation of mRNA into functionally active proteins. Using the latest high-throughput sequencing technologies we have uncovered novel RBP- dependent regulatory mechanisms that control innate and adaptive immune responses. In particular, we are interested on understanding how RBPs differentially modulate gene expression during B lymphocyte activation and their contribution into central nervous system (CNS) autoimmunity. We look for a molecular biologist or immunologist ideally with knowledge into computational analysis. The candidate will generate and integrate data from in-vivo conditional knock out mouse models and from the latest biochemical and sequencing technologies to study the regulation of RNA splicing and translation in B lymphocytes in normal and physiopathology in the CNS.

The successful applicant will be involved in a highly collaborative project between the Center for Phyisiopathology Toulouse Purpan (CPTP, Toulouse) and the Necker Institute (Paris) which is funded by the National Agency for Research (ANR). As part of this team, the applicant will take responsibilities on the characterization of novel mechanisms involved in B cell development and function in different models of autoimmunity including experimental autoimmune encephalomyelitis (EAE).
The postdoctoral fellow will be highly involved in uncovering the molecular mechanisms controlled by RBPs, identifying protein:RNA interactions by iCLIP-seq as well as deep characterization of the transcriptome and translatome of B cells in different settings.
Additionally, the candidate will explore the intracellular and external cues that control RBP function in normal B cell homeostasis and inflammation (in-vivo and in-vitro settings).
The applicant is expected to independently conduct research with support & supervision adapted to previous experience and needs.
The postdoctoral researcher will present the progress of the project in regular internal meetings between the teams involved in the project, as well as during national and international conferences.
The successful applicant will have full support to apply for own national and international fellowships/grants that supports the project as well as career development.

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