Lunds universitet
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State University, Browse similar opportunities
Project description and Work Duties
This project aims to establish the developmental basis of parallel evolution in Mediterranean wall lizards. At least six of the 26 wall lizard species have independently and repeatedly evolved a suite of exaggerated colors, morphologies, and behaviors - a syndrome. While the traits that make up the syndrome are very different, they partly develop from the same developmental cell type, neural crest cells (NCCs). This shared developmental origin in NCCs offers a potential explanation for why these traits "go together" not just in development, but also in evolution.To test this idea, the successful candidate will focus on the NCC biology of wall lizards. This first part of the project involves the analyses of embryonic gene expression profiles of key regulators of NCCs in wall lizards. The successful candidate will be involved in the establishment of cell sorting (FACS) to isolate NCCs. Once established, the PhD student will compare the transcriptomic and epigenetic state of NCCs between lizards of contrasting phenotypes (ancestral vs syndrome lizards). The successful candidate will have the opportunity to develop the research according to his/her own interest and expertise, for example, towards comparative studies that quantifies parallelism at the phenotypic and genomic and genomic level. This PhD position will provide opportunities to develop independent, critical thinking and acquire the skills necessary for conducting scientific projects. The successful candidate will have the opportunity to learn a variety of laboratory-based methods (in situ hybridization, embryology, cell sorting and microscopy), omics techniques (transcriptomics, genomics and epigenetics), multivariate statistics and phylogenetic comparative methods. The project will include working with live animals, both in the lab and in the field. An integral part of this project will be to develop a deep understanding of evolutionary theory.Evolutionary Biology is a major focus area of the Department of Biology. We address a wide range of topics (evolutionary ecology, speciation, evolutionary theory, molecular ecology, experimental evolution, etc.) and as such the successful candidate will be integrated in a lively, stimulating and diverse intellectual environment. There will be a close collaboration with the research group of Prof. Tobias Uller and other international collaborators.
Requirment Profile
It is essential that the candidate has:
- An MSc degree in Biology with a focus on Evolutionary or Developmental Biology or a
closely related field
- A very good understanding of evolutionary theory, developmental biology and genetics
- A good understanding of statistics (preferably multivariate statistics)
- Excellent spoken and written English
- Demonstrated excellent organizational skills
- Experience of molecular biology (e.g., DNA/RNA extraction, gene expression analyses)
It is preferable that the candidate has:
- Experience of bioinformatics analysis of next-generation sequencing data
- Experience of embryology and developmental genetics (preferably in lizards)
- Experience of fieldwork (preferably with lizards)
- Experience of working in a team
- Skills in data handling and statistical analyses in R
We are looking for a self-motivated, creative and solution-oriented candidate with a strong scientific curiosity.
Eligibility
Students with basic eligibility for third-cycle studies are those who have completed a second-cycle degree, have completed courses of at least 240 credits, of which at least 60 credits are from second-cycle courses, or have acquired largely equivalent knowledge in some other way, in Sweden or abroad.
The employment of doctoral students is regulated in the Swedish Code of Statues 1998: 80. Only those who are or have been admitted to PhD-studies may be appointed to doctoral studentships. When an appointment to a doctoral studentship is made, the ability of the student to benefit from PhD-studies shall primarily be taken into account. In addition to devoting themselves to their studies, those appointed to doctoral studentships may be required to work with educational tasks, research and administration, in accordance with specific regulations in the ordinance.
Terms of employment
Only those admitted to third cycle studies may be appointed to a doctoral studentship. Third cycle studies at LTH consist of full-time studies for 4 years. A doctoral studentship is a fixed-term employment of a maximum of 5 years (including 20% departmental duties). Doctoral studentships are regulated in the Higher Education Ordinance (1993:100), chapter 5, 1-7 §§.
Instructions on how to apply
The application should include:
Last application date is 10.01.2021
For questions email main supervisor Dr, Nathalie Feiner. nathalie.feiner@biol.lu.se
Type of employment
Limit of tenure, four yeras according to HF 5 kap 7§
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