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Post-transcriptional regulation by RNA-binding proteins (RBPs) controls all aspects of RNA life, from synthesis, editing, location and translation of mRNA into functionally active proteins. Using the latest high-throughput sequencing technologies we have uncovered novel RBP- dependent regulatory mechanisms that control innate and adaptive immune responses. In particular, we are interested on understanding how RBPs differentially modulate gene expression during B lymphocyte activation and their contribution into central nervous system (CNS) autoimmunity. We look for a molecular biologist or immunologist ideally with knowledge into computational analysis. The candidate will generate and integrate data from in-vivo conditional knock out mouse models and from the latest biochemical and sequencing technologies to study the regulation of RNA splicing and translation in B lymphocytes in normal and physiopathology in the CNS.
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