Postdoc in neural crest and tumor biology: The importance of HIF-2a for neural crest cell migration...

Postdoc in neural crest and tumor biology: The importance of HIF-2a for neural crest cell migration...

Sweden 02 Aug 2021
Lund University LU

Lund University LU

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OPPORTUNITY DETAILS

State University
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Deadline
02 Aug 2021
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Opportunity funding
Full funding
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Announcement of post-doc scholarship at the Division of Pediatrics, Lund University, Sweden

The importance of HIF-2a for neural crest cell migration and its connection to tumor initiation 

It is well known that hypoxia, i.e. low oxygen levels, predicts poor outcome and metastatic burden in a variety of solid tumors. Transcriptionally active Hypoxia Inducible Factors (HIFs) and their downstream target genes orchestrate the cellular adaptation to increased oxygen demands in both normal and tumor cells (Hammarlund, Flashman, Mohlin & Licausi, https://science.sciencemag.org/content/370/6515/eaba3512.long rel="noopener noreferrer" target="_blank">Science 2020). We have recently shown that the cancer-associated protein HIF-2a is important for trunk neural crest stem cell development (Niklasson et al., https://anatomypubs.onlinelibrary.wiley.com/doi/10.1002/dvdy.253 rel="noopener noreferrer" target="_blank">Dev Dyn 2020). In this project, we are interested in investigating how HIF-2a affects early and late neural crest cell migration, population of organs and how this connects to childhood tumor initiation.

The purpose of this scholarship is for the candidate to deepen their skills in the field of molecular physiology. The candidate will acquire theoretical knowledge within the areas of developmental and tumor biology as well as learn a set of methodologies including microdissections, cell culture, cloning, virus work and analyzing omics data. The candidate will learn to handle several different research organisms, including chick embryos and in vivo mouse models.

Preliminary start date: 1st of March 2021 (to be discussed)

Supervisor/contact person: 

Sofie Mohlin

+46-704647998

sofie.mohlin@med.lu.se

https://www.tcr.lu.se/research-groups/molecular-physiology rel="noopener noreferrer" target="_blank">

Twitter: <a">https://www.tcr.lu.se/research-groups/molecular-physiology

Twi... href="https://twitter.com/mohlinlab rel="noopener noreferrer" target="_blank">@mohlinlab

Qualifications: 

  • To be eligible for a post-doc scholarshop at Lund University the recipient must hold a PhD degree within a relevant field. The PhD degree must not be from Lund University. The PhD degree must not be older than three years. The applicant must not have been employed at Lund University in the past two years.
  • Obtained PhD within cancer research, developmental biology or equivalent.
  • Published papers in peer-reviewed international journals
  • Fluent in written and spoken English

The following qualifications are advantageous but not necessary: 

Experience in:

  • Analyzing omics data (e.g., RNA sequencing and mass spectrometry)
  • In vivo models (e.g., chick embryo, mice, rats, zebrafish)
  • Wet lab techniques
  • Imaging

The candidate will be part of a team, but at the same time needs to be independent enough to lead their own projects. The candidate should be fluent in English and have experience from oral and written scientific communication.

We put great emphasis on personal suitability.

Written application, including reference number, is to be sent via e-mail to the supervisor and must include the following: 

  • CV
  • Personal letter stating the reasons why the study suits the applicant (maximum one page)
  • List of publications
  • References (2)
  • PhD diploma

Application deadline: February 8, 2021 

Reference number: V 2021/24

">https://www.med.lu.se/intramed/stipendier_anslag_fraan_fakulteten/#item_...


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