18-months Post-doc position in organic chemistry (M/F)

18-months Post-doc position in organic chemistry (M/F)

France 02 Aug 2021


Research Center, Browse similar opportunities


Research Center
Host Country
02 Aug 2021
Study level
Opportunity type
Opportunity funding
Full funding
Eligible Countries
This opportunity is destined for all countries
Eligible Region
All Regions

-Synthesis of various chiral CAAC ligand precursors (iminium salts)
-Synthesis of various chiral CAAC-based Ru-complexes
-Evaluation in asymmetric ring-closing metathesis (ARCM) and cross-metathesis (ACM)
-Synthesis of enantioenriched relevant building blocks

In a few decades, olefin metathesis has rapidly become one of the most efficient synthetic tools in organic chemistry, thanks to the development of efficient, well-defined, air stable and easy to handle N-heterocyclic carbenes (NHCs) ruthenium-arylidene complexes with high tolerance towards many organic functions. Asymmetric version of this tool was also investigated with a slew of Ru-complexes featuring chiral NHCs with varying successes in ring-opening cross-metathesis (AROCM) and ring-closing metathesis (ARCM). In 2007, a new class of carbenes namely cyclic (alkyl)(amino) carbenes (CAACs) arose as a contender to NHCs's as ligands for olefin metathesis catalysts. Since then, CAAC-Ru complexes demonstrated remarkable catalytic performances in a number of metathesis transformations. Despite these achievements there is still no report dealing with CAAC ligands in asymmetric metathesis. On this concern, we recently developed an expedient access to a range of optically pure, well-defined Ru-complexes containing chiral CAACs. It relies on an efficient resolution of their racemic mixture via chiral prepHPLC on chiral-stationary phase. This process allowed for the isolation of air-stable (+) and (–)-enantiomers in nearly quantitative yields and excellent optically purity (>98%). Using these catalysts, excellent performances were observed in AROCM with high enantioselectivities (up to 92% ee).
During this Post-doc position, the researcher will synthesize a library of unprecedented optically pure CAAC-Ru complexes. These new catalysts will be subsequently evaluated in asymmetric ring-closing metathesis (ARCM) and cross-metathesis (ACM) targeting synthesis of original chiral building blocks for agrochemical industry and perfumery.

Organometallics: Materials and Catalysis (OMC) TEAM located at ENSC of Rennes
Supervisor : Dr. Marc MAUDUIT

Other organizations

Choose your study destination

Choose the country you wish to travel to study for free, work or volunteer

Please find also