Postdoc Position on the Role of Heterozygous Loss of Ribosomal Proteins RPL5 and RPL11 in Cancer

OPPORTUNITY DETAILS

Total reward

0 $

State University

KU Leuven

Area

Western Europe

Host Country

Belgium

Deadline

01 Mar 2021

Study level

Doctoral Degree

Opportunity type

PhD

Specialities

Medicine , Biology , Chemistry

Opportunity funding

Not funding

Eligible Countries

This opportunity is destined for all countries

Eligible Region

All Regions

(ref. BAP-2021-74)

The laboratory for Disease Mechanisms in Cancer (KU Leuven, Belgium, www.LDMC.be) is looking for a motivated postdoctoral researcher. Our team identified somatic mutations in ribosomal proteins in cancer. To understand how mutations in this essential cellular machinery promote tumorigenesis, we characterize the impact of ribosomal protein mutations on the spectrum of expressed proteins in cancer cells (cellular translatome). In the past, our work mainly focused on the role for the ribosomal RPL10 R98S point mutation that is implicated in leukemia. Ribosomal proteins RPL5 and RPL11 are heterozygously lost in 10-35% of various cancer types. In this project, the downstream consequences of such a heterozygous loss of RPL5 and RPL11 in cancer cells will be studied in breast cancer and glioblastoma cell culture and mouse models using proteome and phospho-proteome based methodologies.

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The successful candidate will continue an ongoing research line in the lab to characterize the role of heterozygous loss of ribosomal proteins RPL5 and RPL11 in cancer. He/ she will perform proteomics screenings and biochemical experiments in cell culture and mouse models to identify the cancer promoting downstream consequences of RPL5/RPL11 loss. The successful applicant will also help in supervising PhD students in the lab and will be involved in writing of scientific papers, project reports and grant applications.

Starting date: To be negotiated. Any date after March 1st 2021.

For more information please contact Prof. dr. Kim De Keersmaecker, tel.: +32 16 37 31 67, mail: kim.dekeersmaecker@kuleuven.be.

You can apply for this job no later than March 01, 2021 via the online application tool

KU Leuven seeks to foster an environment where all talents can flourish, regardless of gender, age, cultural background, nationality or impairments. If you have any questions relating to accessibility or support, please contact us at diversiteit.HR@kuleuven.be.