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The French National Research Institute for Agriculture, Food, and the Environment (INRAE) is a public research establishment under the dual authority of the Ministry of Agriculture and the Ministry of
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19 Apr 2021
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Human Nutrition unit                                                                  Dr. Sergio Polakof

INRAE, Clermont-Ferrand                                                           33 (0)4 73 62 48 95          

France                                                                                          sergio.polakof@inrae.fr

https://www6.clermont.inrae.fr/unh_eng/Teams/IMPROVING

Starting date: Spring 2021.

Funding: iSITE International, MetaMob project.

Scientific project:

Frailty is characterized by the loss of physiological homeostasis and capability to handle modifications of its environment. It is partly driven by mobility capacities and nutritional features. To minimize risks, optimize outcomes and maintain independency for aged patients, it is important to identify the level of frailty rapidly
and accurately even in non-geriatric services. Here, in a German cohort of elderly patients, we aim at obtaining a metabolomics-based signature able to identify at discharge, those metabotypes potentially responsive to future (at home) nutritional and/or physical activity interventions. This tool would provide a more accurate and
fast diagnosis, improving the identification of the patient needs and enabling a more personalized care pathway during the hospital stay and after discharge.

Keywords: elderly, metabolomics biomarkers, nutritional status, mobility, frailty

Location:

The fellow will be recruited by the Université Clermont Auvergne/INRAE (France) but will be required to carry out  first his/her research work at the Charité University Hospital in Berlin under the supervision of Pr. K. Norman ( PhD,Charité Berlin and DIfE Postdam) and  then, at the INRAE Research Centre in France. In Germany, a clustering of the geriatric patients of the Wonder cohort (n=500) will be made and in France, the metabolomics analyses will be carried out with the management, interpretation and modeling of the big data generated.

Salary:   2 100-2 400€ net of charge per month depending on the years of expertise after the PhD.

Duration: 18 months

Expertise/Background requested: The candidate must have training and skills focused on biology with a particular interest in metabolism, metabolomics and epidemiology. Knowledge of statistics (univariate, multivariate, clustering, predictive models) and metabolomics data analysis and treatment are also requested. The training of various skills (biochemistry, nutrition) within a transdisciplinary project supervised by several specialists should be a central motivation of the candidate. Fluency in English is required.

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