en
State University (France), Browse similar opportunities
SL-DRT-21-0634
Health and environment technologies, medical devices
The rapid inexorable spread of antibiotic resistance is one of the critical challenges in health care for the coming decade. Patients increasingly encounter dead-ends, with no effective molecule. The quest for alternatives to antibiotic therapy is a major public health issue and should, according to the WHO, be given priority status. Phage therapy uses viruses known as bacteriophages, or “phages” for short, that specifically infect and destroy bacteria without impact on human cells. They have been used for decades in some countries in Eastern Europe, but preparations from these countries cannot be imported in France or Western European countries as they fail to meet standard drug agency criteria (ANSM, EMEA).Some new techniques have to be developed and optimized for a better and faster characterization of these therapeutic viruses, during their amplification and purification, as well as during their storage or juste before dispensing medication. The study deals with innovative approaches based on microelectronics and nanotechnologies for rapid in-vitro quantification and characterization of therapeutic phages to facilitate selection of phages and QCs of phage therapeutic products: (i) a lensless imaging technique for fast phage titration based on the monitoring of lysis plaques (from 20-µm- to millimeter-size) over a wide field-of-view (up to at least 864 mm2), suited to continuous detection of phage plaque growth, (ii) a microsystem called SNR (Suspended Nanochannel Resonator) for phage purity assessment without culture/replication requirement based on rapid mass measurement of individual virions.
Département Microtechnologies pour la Biologie et la Santé (LETI)
Laboratoire Chimie, Capteurs et Biomatériaux
Grenoble
MARCOUX Pierre R.
CEA
DRT/DTBS
DTBS, bât. 42CEA - LETI MINATEC17, rue des MartyrsF-38054 Grenoble cedex 9
Phone number: 04 38 78 15 04
Email: pierre.marcoux@cea.fr
Université Grenoble Alpes
Ecole Doctorale de Physique de Grenoble
https://www.linkedin.com/in/pierre-r-marcoux/
https://www.linkedin.com/in/vincentagache/
Start date on 01-10-2021
AGACHE Vincent
CEA
DRT/DTBS/LSMB
Phone number: 0438782653
Email: vincent.agache@cea.fr
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