en

Postdoctor in Control of Biopharmaceutical Processes

Postdoctor in Control of Biopharmaceutical Processes

Sweden 15 Feb 2021
KTH Royal Institute of Technology

KTH Royal Institute of Technology

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OPPORTUNITY DETAILS

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State University
Area
Host Country
Deadline
15 Feb 2021
Study level
Opportunity type
Specialities
Opportunity funding
Not funding
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This opportunity is destined for all countries
Eligible Region
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KTH Royal Institute of Technology in Stockholm has grown to become one of Europe’s leading technical and engineering universities, as well as a key centre of intellectual talent and innovation. We are Sweden’s largest technical research and learning institution and home to students, researchers and faculty from around the world. Our research and education covers a wide area including natural sciences and all branches of engineering, as well as architecture, industrial management, urban planning, history and philosophy.

Job description

The biopharmaceutical industry is a large and profitable field. Bioproduction has evolved from being based on bacterial systems towards production based on mammalian cells in a majority of biological drugs. The production is taking place in intracellular metabolic reaction networks. The legacy is to grow cell cultures in fed-batch bioreactors, but the field is rapidly evolving as a result of new trends and a constantly increasing competition. In this perspective, integrated continuous bioprocessing, i.e. a process consisting of a perfusion cell culture where a medium is steadily added, has received significant attention both from industry and academia. This interest is rapidly increasing and nearly all the large Pharma/Biotech companies are looking into this type of intensified process.

Modeling and control will play a key role in enabling advanced bioprocesses for the production of biopharmaceuticals. Through several projects, we are building a sustainable world-class environment for modeling and control of intracellular networks and cell cultures for bioproduction. Currently, the team involves two Full Professors with specializations in data-driven modeling and control, two postdocs, and one Ph.D student. We are recruiting new members to the group.

This advertised postdoc position is part of the EU project iConsensus with the objective to develop new on-line and at-line sensors and use these to optimize and control cell cultures and their products. The project, led by KTH, involves several leading European biopharmaceutical companies and universities. The postdoc position will also be associated with the Centre for Advanced Bioproduction (AdBIOPRO), led by KTH, and in collaboration with Lund University and Karolinska University Hospital as well as seven Swedish companies in the Biopharmaceutical/Biotech industry, including GE Healthcare. The Centre focuses on bioproduction based on mammalian cells, with the objective to respond to the paradigm shift towards continuous processing and to become world-leading.

This project concerns optimization and model-based control of intracellular networks and cell cultures by manipulating culture media and other process parameters. It involves developing methodologies for optimizing cell metabolism through media feeds, and advanced model-based feedback control based on newly developed models and on-line and at-line sensors. The project is in close collaboration with the School of Chemistry, Biotechnology and Health at KTH, world-leading in continuous bioprocessing and hosting extensive laboratory facilities, and our industrial partners, with the ultimate objective to verify methodologies in an industrial setting.

For the successful candidate, the project provides an excellent starting point for a career in a rapidly evolving field.

What we offer

Read more about what it is like to work at KTH

Qualifications

Requirements

A doctoral degree or an equivalent foreign degree, in Electrical Engineering, Chemical Engineering or Biotechnology. The doctoral degree must have been obtained within the last three years prior to the application deadline (with some exceptions for special reasons such as periods of sick or parental leave, kindly indicate if such reason exists in your resume).

The candidate should have a strong background in at least one of the areas; biosystems modeling, model-based control or optimization, and experience from at least one more of these areas.

There are high requirements on outstanding research and publication record. Well-developed analytical and problem-solving skills are also required. We are looking for a strongly motivated person, who can work both independently and in collaboration with others. Good command of English orally and in writing is required to present and publish research results.

Great emphasis will be placed on personal competency

Trade union representatives

You will find contact information to trade union representatives on KTH's webbpage.

Application

The application should include:

Log into KTH's recruitment system to apply for this position. You are the main responsible to ensure that your application is complete according to the ad.

Your complete application must be received at KTH no later than the last day of application, midnight CET/CEST (Central European Time/Central European Summer Time).

About the employment

The offered position is time-limited to 1 year with the possibility of extension with 1 more year.

A position as a postdoctoral fellow is a time-limited qualified appointment focusing mainly on research, intended as a first career step after a dissertation.

Others

Striving towards gender equality, diversity and equal conditions is both a question of quality for KTH and a given part of our values.

For information about processing of personal data in the recruitment process please read here.

We firmly decline all contact with staffing and recruitment agencies and job ad salespersons.

Disclaimer: In case of discrepancy between the Swedish original and the English translation of the job announcement, the Swedish version takes precedence.

Type of employment: Contract type: First day of employment: Salary: Number of positions: Working hours: City: County: Country: Reference number: Contact: Published: Last application date:

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