Project in the School of Life Sciences MRC IMPACT Doctoral Training Partnership

OPPORTUNITY DETAILS

Total reward

0 $

State University

University of Nottingham

Area

Central and Eastern Europe

Host Country

United Kingdom

Deadline

02 Mar 2021

Study level

Doctoral Degree

Opportunity type

PhD

Specialities

Medicine , Biology

Opportunity funding

Not funding

Eligible Countries

This opportunity is destined for all countries

Eligible Region

All Regions

Reference MED1581

Closing Date Tuesday, 2nd March 2021

Department Life Sciences

Applications are open for a range of exciting projects around the theme of complex disease.

These 42-month PhD studentships, starting in October 2021, are offered through IMPACT – a doctoral training partnership between the Universities of Birmingham, Leicester and Nottingham. The University of Nottingham is advertising 8 projects in order to recruit to 4 studentships (2 IMPACT and 2 iCASE) in total.

You will study alongside other PhD students across a diverse range of projects, enabling you to think creatively and perform innovative, world- leading research. You will also benefit from the expertise of our research partner, the Research Complex at Harwell.

Applications will close at 5.00 pm on 7 January 2021. Funding is provided by the Medical Research Council. Please ensure that your application is submitted with all required documentation as incomplete applications will not be considered.

Full information about the eligibility criteria and application process are on the MRC IMPACT DTP website.

The following IMPACT project is available in the School of Life Sciences:

Single molecule analysis of myotonic dystrophy mutant transcripts - Professor David Brook

Myotonic Dystrophy is the most common form of muscular dystrophy in adults. It is caused by transcribed repeat expansion sequences that remain in the nuclei of patients’ cells where they form distinct foci or spots, which interfere with key molecular processes. We are developing therapeutic compounds for this condition which eliminate the foci in patients’ cells. This project aims to understand the underlying molecular mechanisms that lead to foci formation and disruption, using state-of the-art microscopy and image analysis, alongside novel RNA sequencing techniques. Using a combination of molecular cell biological approaches, it should be possible to determine the molecular mechanism underlying foci formation and therefore improve attempts to develop a treatment for this condition.