Sorbonne University UMR S 1166 ICAN
Universidad Estatal, Examinar oportunidades similares
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Universidad Estatal, Examinar oportunidades similares
The UMRS 1166 – ICAN (Research unit on cardiovascular and metabolic diseases) is a dynamic research center located in Paris center that comprises internationally recognized groups focusing on cardiovascular and metabolic diseases.
We seek to hire a highly motivated postdoctoral fellow to investigate the (co)trafficking of sodium channel and protein partners in the team led by Elise Balse at the UMRS 1166-ICAN, in collaboration with the team of Franck Perez, head of the cell Biology and Cancer Unit at the Curie Institute, Paris.
The post doctorate will work with research assistants and scientists to transpose the Retention using selective hooks (RUSH) system in cardiac myocytes. RUSH is a two-state assay based on the reversible interaction of a hook protein fused to core streptavidin and stably anchored in a donor compartment (e.g. ER) with a fluorescent reporter protein of interest fused to streptavidin-binding peptide (SBP). Biotin addition causes a synchronous release of the reporter from the hook. Therefore, the flow of different proteins, here ion channels and regulatory partners, can be visualized and quantitated simultaneously.
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