Post-doctoral position in membrane protein biochemistry and structural biology
CNRS
Centro de Investigación, Examinar oportunidades similares
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Centro de Investigación, Examinar oportunidades similares
-Molecular biology and protein engineering (mutagenesis, unnatural amino acid labelling)
-Membrane protein expression and purification
-sample reconstitution in membrane-mimicking environment (nanodisc)
-Biochemical and pharmacological characterisation of purified receptors.
-Crystallisation in lipidic cubic phase
-Results analysis.
The selected candidate will developed a research project that aim at deciphering the activation mechanism of G protein coupled receptors (GPCRs). The candidate will express and purify GPCR and GPCRs signalling complexes and performed biophysical and structural characterisation of the purified receptor. The main objective is to decipher the structural dynamics of GPCR at the atomic scale.
The IGF is University, CNRS and INSERM research unit located on the Medical Sciences campus in Montpellier (http://www.igf.cnrs.fr ). IGF 19 research teams develop multidisciplinary research project from the atomic scale to animal model. Our institute is internationally established in the field of GPCRs and molecular pharmacology and provide a state of the art research environment.
The selected candidate will be part of the team Molecular and structural mechanism of neuromodulation, in the neuroscience department.
We are seeking a highly motivated biochemist with experience in molecular biology, membrane protein expression (insect and mammalian cells) and purification. Experience with membrane protein cystallisation would also be appreciated but not essential, as training will be provided.
For application, a letter of motivation, a CV and the names of referees should be sent to Guillaume Lebon: guillaume.lebon@igf.cnrs.fr
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