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Post-doctoral position in cell and molecular biology at Unité de Recherche INSERM-Paris-Saclay 1193...

Post-doctoral position in cell and molecular biology at Unité de Recherche INSERM-Paris-Saclay 1193...

France 05 déc. 2022
INSERM U1193 UNIVERSITY Paris Saclay

INSERM U1193 UNIVERSITY Paris Saclay

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European Commission › EURAXESS › Jobs & Funding › Post-doctoral position in cell and molecular biology at Unité de Recherche INSERM-Paris-Saclay 1193, Centre hépatobiliaire, Hôpital Paul Brousse, Villejuif (France).
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12/04/2022
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Post-doctoral position in cell and molecular biology at Unité de Recherche INSERM-Paris-Saclay 1193, Centre hépatobiliaire, Hôpital Paul Brousse, Villejuif (France).
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Post-doctoral position in cell and molecular biology at Unité de Recherche INSERM-Paris-Saclay 1193, Centre hépatobiliaire, Hôpital Paul Brousse, Villejuif (France).
Application Deadline: 12/05/2022 00:00 - Europe/Brussels
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INSERM U1193, UNIVERSITY Paris Saclay

  • WEBSITE
    https://www.abg.asso.fr/fr/candidatOffres/show/id_offre/104647

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  • ORGANISATION/COMPANY
    INSERM U1193, UNIVERSITY Paris Saclay

  • ORGANISATION TYPE
    Other

  • COUNTRY
    France

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  • ORGANISATION/COMPANY
    INSERM U1193, UNIVERSITY Paris Saclay

  • RESEARCH FIELD
    Biological sciencesBiology
    Medical sciences

  • RESEARCHER PROFILE
    First Stage Researcher (R1)
    Recognised Researcher (R2)
    Established Researcher (R3)
    Leading Researcher (R4)

  • APPLICATION DEADLINE
    12/05/2022 00:00 - Europe/Brussels


  • LOCATION
    France › Villejuif

  • TYPE OF CONTRACT
    Temporary

  • JOB STATUS
    Full-time

OFFER DESCRIPTION

The infection with hepatitis C virus (HCV) is a major risk factor for the development of hepatocellular carcinoma (HCC). Although new therapeutic approaches seem to eradicate HCV, it does not completely eliminate the risk of HCC. At present, there is no effective treatment of HCC apart from heavy surgeries (resection, transplantation) and its incidence is increasing worldwide. The development of HCC is strongly dependent on a cascade of morphogenesis events following the activation of cellular signalling pathways. HCC develops from polarized epithelial cells of the liver that are hepatocytes, which have remarkable plasticity and can thus undergo cycles of de-differentiation, division and differentiation to ensure the regeneration of the liver. Unfortunately, in severe pathological conditions, this cellular plasticity can lead to an irreversible process of de-differentiation of hepatocytes to a status of stem cells and thus support the development of an aggressive cancer that is often resistant to treatment. We have demonstrated the key role of the δ isoform (PI3Kδ) of class I phosphoinositide-3 kinases in cell polarity, extracellular matrix (ECM) assembly in epithelial cells. The aim is to decipher how PI3Kd-dependent signalling pathways control plasticity and the development of HCV induced HCC resistant to treatment. The main techniques involved 3D organoid cultures from cell lines and biopsies from patients with HCV induced HCC, confocal analysis and immunohistochemistry. Epigenetic and transcriptomic and bioinformatic studies will be performed.   The candidate must be familiar with advanced imaging technics and software and should have ability to drive its own research. Background in cell biology and cell signaling is required. Knowledge on HCV and bioinformatics are advantages.  


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Doctorat d'université


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1 position(s) available at
INSERM U1193, UNIVERSITY Paris Saclay
France
Villejuif

EURAXESS offer ID: 771050
Posting organisation offer ID: 104647


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